Mandrake Root

Also known as- Podophyllum peltatum, mayapple.

Introduction

The mandrake is a relative of barberry and goldenseal found in the eastern half of North America. Plants grow 6 to 18 inches (15 to 40 cm) tall in patches, producing a single stalk capped with an "umbrella" of one or two deeply indented leaves. The plant blooms with a single small white flower that produces a single yellow, mushy berry, the only part of the plant that can be eaten safely„in moderation.
Native Americans used mandrake as an emetic (to induce vomiting), as a cathartic (to relieve severe constipation), and as an escharotic (to remove unusual growths of the skin). The latter property is now most valued, podophyllum resin being employed externally in the treatment of venereal warts and similar papillomas caused by viral infection.

Constituents

At least 4% resin with podophyllotoxin, alpha-petalin, and beta-petalin.

Parts Used

The dried root.

Typical Preparations

For topical application only, usually in ointment or tincture.

Summary

In Japan, mandrake is used to make Hakkakuren, an over the counter preparation for removing genital warts. Other preparations of mandrake or podophyllum resin are used for the same purpose in Europe, Australia, and North America.
Although the herb contains berberine, it cannot be used interchangeably with barberry and goldenseal. More than a very small dose of mayapple taken by mouth can cause violent vomiting or diarrhea.

Precautions

Do not take internally. The treated skin surface must not be larger than 25 cm2 (approximately 3 inches by 3 inches). Be sure to protect skin adjacent to treated area. If administered medicinally, it is recommended to be done so by a qualified practitioner.

 

For educational purposes only
This information has not been evaluated by the Food and Drug Administration.
This information is not intended to diagnose, treat, cure, or prevent any disease.

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